Control of microenvironment around enzymes by hydrogels.

Yuichiro KobayashiKenji KoharaYusuke KiuchiHiroki Onoda Osami Shoji Hiroyasu Yamaguchi

Published in: Chemical communications (Cambridge, England) (2021)

We prepared enzyme-immobilized hydrogels and investigated the effects of the cross-linking density and polymer properties on their oxidation reaction rate. The oxidation rate of enzyme-immobilized hydrogels increased as the cross-linking density in the hydrogels increased. In addition, we controlled the oxidation rate using hydrogels exhibiting an appropriate interaction with a decoy molecule in the hydrogel.

Keyphrases

hyaluronic acid
drug delivery
tissue engineering
wound healing
drug release
extracellular matrix
hydrogen peroxide
stem cells
electron transfer
visible light
atomic force microscopy
high resolution