Phenotypic and Genomic Characterization of ST133 Siderophore-Encoding Extensively Drug-Resistant Enterobacter hormaechei.
Yonglu HuangYuchen WuChang CaiRong ZhangGongxiang ChenNing DongPublished in: Antimicrobial agents and chemotherapy (2023)
We identified an ST133 extensively drug-resistant Enterobacter hormaechei, C210017, with increased virulence in the Galleria mellonella infection model. Genomic analysis suggested it carried antibiotic resistance genes bla KPC-2 and mcr-9.1 , and genes iutAiucABCD and iroBCDEN encoding the virulence factor, siderophores. Comparative genomics of C210017 and the 178 ST133 E. hormaechei strains in the database suggested they all belonged to serotype O3 and most strains (77.5%) carried the IncHI2 superplasmids associated with the resistance, virulence, and adaptation of the host strain.
Keyphrases
- drug resistant
- multidrug resistant
- klebsiella pneumoniae
- escherichia coli
- acinetobacter baumannii
- antibiotic resistance genes
- pseudomonas aeruginosa
- biofilm formation
- staphylococcus aureus
- antimicrobial resistance
- wastewater treatment
- microbial community
- anaerobic digestion
- single cell
- cystic fibrosis
- gene expression
- copy number
- zika virus
- emergency department
- candida albicans