Abnormal activation of NF-κB and MAPK signaling pathways affect osimertinib resistance and influence the recruitment of myeloid-derived suppressor cells to shape the immunosuppressive tumor immune microenvironment.
Chao WangKailun FeiLihui LiuJianchun DaunZhijie WangSini LiJiachen XuXue ZhangYanhua TianYan QuHua BaiJie WangPublished in: Thoracic cancer (2023)
Thus, our findings lay the foundation for the evolution of TIME in osimertinib treatment, establish the mechanism of immunosuppressive TIME after osimertinib resistance, and propose potential solutions.
Keyphrases
- signaling pathway
- small cell lung cancer
- induced apoptosis
- advanced non small cell lung cancer
- epidermal growth factor receptor
- pi k akt
- cell cycle arrest
- oxidative stress
- epithelial mesenchymal transition
- stem cells
- tyrosine kinase
- cell death
- endoplasmic reticulum stress
- immune response
- inflammatory response
- climate change