Self-reporting heavy atom-free photodynamic therapy agents.
Gulsen TurkogluGozde Kayadibi KoygunMediha Nur Zafer YurtNaime DemirokSundus Erbas-CakmakPublished in: Organic & biomolecular chemistry (2022)
Two novel, self-reporting distyryl BODIPY-based photodynamic therapy agents functionalized with singlet oxygen responsive imidazole and tertiary amine moieties are developed. Heavy atom-free photosensitizers are demonstrated to have efficient photodynamic action in MCF7 cells. The fluorescence intensity of the photosensitizers is shown to be reduced as a result of 1O2 generation without any significant change in photodynamic activity.
Keyphrases
- photodynamic therapy
- cancer therapy
- fluorescence imaging
- induced apoptosis
- adverse drug
- molecular dynamics
- cell cycle arrest
- drug delivery
- energy transfer
- breast cancer cells
- quantum dots
- single molecule
- electron transfer
- high intensity
- endoplasmic reticulum stress
- fluorescent probe
- cell death
- simultaneous determination
- liquid chromatography