The efficacy of quantitative fetal fibronectin in predicting spontaneous preterm birth in symptomatic women: A retrospective cohort study.
Anh Duy NguyenCathy Zhenao LiuChristoph LehnerAkwasi Atakora AmoakoRenuka SekarPublished in: The Australian & New Zealand journal of obstetrics & gynaecology (2019)
The overall rate of sPTB <34 weeks was 4.1% (n = 373). For deliveries within 48 h, within 14 days and <34 weeks, a qfFN threshold of 200 ng/mL had positive predictive values of 26.7%, 42.9% and 46.7%, respectively, when compared to patients with qfFN values of 0-9 ng/mL. The corresponding relative risks were 68.5, 53.8 and 38.0, respectively CONCLUSION: Quantitative fetal fibronectin testing with thresholds of 10, 50 and 200 ng/mL allows for more accurate prediction of preterm birth in symptomatic women. This higher degree of discrimination allows for more directed interventions for high-risk patients and reduces the cost and burden of unnecessary treatment for low-risk patients.
Keyphrases
- preterm birth
- end stage renal disease
- gestational age
- chronic kidney disease
- high resolution
- low birth weight
- peritoneal dialysis
- polycystic ovary syndrome
- prognostic factors
- physical activity
- type diabetes
- adipose tissue
- metabolic syndrome
- pregnant women
- risk assessment
- patient reported
- risk factors
- pregnancy outcomes
- replacement therapy
- cervical cancer screening