Clinical and immunological correlates of vasodilatory shock among Ebola virus infected nonhuman primates in a critical care model.

Sydney R SteinAndrew P PlattHeather L TeagueScott M AnthonyRebecca J ReederKurt CooperRussell ByrumDavid J DrawbaughDavid X LiuTracey L BurdetteKyra HadleyBobbi BarrSeth WarnerFrancisco Rodriguez-HernandezCristal JohnsonPhil StanekJoseph HischakHeather KendallLouis M HuzellaJeffrey R StrichRichard HerbertMarisa St ClaireKevin M VannellaMichael R HolbrookDaniel S Chertow

Published in: The Journal of infectious diseases (2023)

Our model allows for high fidelity characterization of the pathophysiology of acute Ebola virus infection with host innate and adaptive immune responses, which may advance host-targeted therapy design and evaluation for use after the onset of multi-organ failure.

Keyphrases

immune response
liver failure
dendritic cells
intensive care unit
drug induced
toll like receptor
hepatitis b virus
aortic dissection
mechanical ventilation