Evaluation of Circulating Tumor DNA for Methylated BCAT1 and IKZF1 to Detect Recurrence of Stage II/Stage III Colorectal Cancer (CRC).

Benjamin L MusherJoshua E MelsonGianni AmatoDavid ChanMarisa HillIftekhar KhanSamith T KochuparambilSusan E LyonsJames OrsiniSusanne K PedersenBruce RobbJoel SaltzmanJennifer SilinskySnigdha Gaur Melissa K Tuck Lawrence C LaPointe Graeme Paul Young

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2020)

This prospective study showed that COLVERA (a two-gene ctDNA assay) was more sensitive for detection of recurrence in a cohort of patients undergoing surveillance after definitive therapy for stages II and III colorectal cancer.

Keyphrases

circulating tumor
patients undergoing
cell free
circulating tumor cells
free survival
acute lymphoblastic leukemia
high throughput
copy number
genome wide
loop mediated isothermal amplification
squamous cell carcinoma
locally advanced
gene expression
transcription factor