TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis.
Paôline LaurentBenoit AllardPauline ManickiValérie JolivelEmeline LevionnoisMohamed JeljeliPauline HenrotJulien IzotteDamien LeleuAlexis GroppiJulien SeneschalJoel ConstansCarlo ChizzoliniChristophe RichezPierre DuffauEstibaliz LazaroEdouard ForcadeThierry SchaeverbekeThomas PradeuFrédéric BatteuxPatrick BlancoCécile Contin-BordesMarie-Elise TruchetetPublished in: Annals of the rheumatic diseases (2021)
Our results demonstrate a novel role for natural ILC2 and highlight their inter-relationships with TGFβ and IL10 in the development of skin fibrosis, thereby opening up new therapeutic approaches in SSc.