Effect of preoperative biliary drainage on cholestasis-associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma.
Megan J ReiniersL de HaanR WeijerJ K WiggersA JongejanP D MoerlandL K AllesA H C van KampenT M van GulikM HegerR F van GolenPublished in: The British journal of surgery (2018)
Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures.
Keyphrases
- genome wide
- copy number
- ultrasound guided
- patients undergoing
- oxidative stress
- minimally invasive
- genome wide identification
- idiopathic pulmonary fibrosis
- drug induced
- squamous cell carcinoma
- machine learning
- bone marrow
- gene expression
- atrial fibrillation
- deep learning
- percutaneous coronary intervention
- bioinformatics analysis