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Mesojunction-Based Design Paradigm of Structural DNA Nanotechnology.

Tianqi WangTanxi BaiZhenyu TanYoel P OhayonRuojie ShaSimon VecchioniNadrian C SeemanBryan Wei
Published in: Journal of the American Chemical Society (2023)
Mesojunctions were introduced as a basic type of crossover configuration in the early development of structural DNA nanotechnology. However, the investigations of self-assembly from multiple mesojunction complexes have been overlooked in comparison to their counterparts based on regular junctions. In this work, we designed standardized component strands for the construction of complex mesojunction lattices. Three typical mesojunction configurations with three and four arms were showcased in the self-assembly of 1-, 2-, and 3-dimensional lattices constructed from both a scaffold-free tiling approach and a scaffolded origami approach.
Keyphrases
  • single molecule
  • circulating tumor
  • cell free
  • wastewater treatment
  • nucleic acid
  • open label
  • double blind
  • clinical trial
  • placebo controlled
  • clinical evaluation