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The Regulating Effect of Autophagy-Related MiRNAs in Kidney, Bladder, and Prostate Cancer.

Kai HuangXiaoxin SunHaotian WuJun ZhaoYuli JianZhongyang XuShujing WangDeyong Yang
Published in: Journal of oncology (2021)
Autophagy is a treatment target for many disorders, including cancer, and its specific role is becoming increasingly well known. In tumors, researchers pay attention to microribonucleic acids (miRNAs) with regulatory effects to develop more effective therapeutic drugs for autophagy and find new therapeutic targets. Various studies have shown that autophagy-related miRNAs play an irreplaceable role in different tumors, such as miR-495, miR-30, and miR-101. These miRNAs are associated with autophagy resistance in gastric cancer, non-small cell lung cancer, and cervical cancer. In recent years, autophagy-related miRNAs have also been reported to play a role in autophagy in urinary system tumors. This article reviews the regulatory effects of autophagy-related miRNAs in kidney, bladder, and prostate cancer and provides new ideas for targeted therapy of the three major tumors of the urinary system.
Keyphrases
  • cell death
  • endoplasmic reticulum stress
  • prostate cancer
  • signaling pathway
  • oxidative stress
  • cell proliferation
  • long non coding rna
  • long noncoding rna
  • transcription factor