Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet.
Meng ZhaoLingyun MaTakashi HondaAsuka KatoTaichi OhshiroShinya YokoyamaKenta YamamotoTakanori ItoNorihiro ImaiYoji IshizuMasanao NakamuraHiroki KawashimaNoriko M TsujiMasatoshi IshigamiMitsuhiro FujishiroPublished in: Digestive diseases and sciences (2022)
Our findings suggest that ASTX alleviates CDHF-OVX-induced pathohistological NASH with downregulated OPG, possibly via suppression of the transforming growth factor beta pathway. ASTX could has promise for use in postmenopausal women diagnosed with NASH.
Keyphrases
- high fat diet
- postmenopausal women
- transforming growth factor
- bone mineral density
- epithelial mesenchymal transition
- insulin resistance
- adipose tissue
- high fat diet induced
- high glucose
- diabetic rats
- signaling pathway
- cell proliferation
- wild type
- nuclear factor
- type diabetes
- big data
- drug induced
- endothelial cells
- oxidative stress
- body composition
- bone loss
- artificial intelligence