Sex differences in perihematomal edema volume and outcome after intracerebral hemorrhage.
Jens WitschQuy CaoJae W SongYunshi LuoKelly L SloaneAaron RothsteinChristopher G FavillaBrett L CucchiaraScott E KasnerSteve R MesséHuimahn A ChoiLouise D McCulloughStephan A MayerAaron M GusdonPublished in: medRxiv : the preprint server for health sciences (2023)
The finding of heightened early PHE and ICH expansion in men may inform study design, patient recruitment strategies, and pre-specification of subgroup analyses in future interventional trials. The findings of this study also suggest that focusing on sex-specific factors may allow novel mechanistic insight into PHE, a major cause of secondary injury and poor outcome after ICH.