DEFINE: A Prospective, Randomized, Phase 4 Trial to Assess a Protease Inhibitor-based Regimen Switch Strategy to Manage Integrase Inhibitor-related Weight Gain.

David AndersonMoti RamgopalDebbie P HaginsJohnnie LeeRichard Bruce SimonsonTien-Huei HsuPing XuNina AhmadWilliam R Short

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)

While no significant change in body weight was observed at 24 weeks after switching from InSTI+TAF/FTC to D/C/F/TAF among adults with weight gain, a trend towards weight loss emerged with longer time post-ARV switch, supporting further investigation of antiretroviral selection/switch for weight management.

Keyphrases

weight gain
weight loss
body weight
body mass index
birth weight
bariatric surgery
roux en y gastric bypass
gastric bypass
hiv infected
human immunodeficiency virus
hiv positive
physical activity
hiv aids
type diabetes
glycemic control
men who have sex with men