Oxycodone-induced tolerance to respiratory depression: reversal by ethanol, pregabalin and protein kinase C inhibition.

Rob HillWilliam L DeweyEamonn KellyGraeme Henderson

Published in: British journal of pharmacology (2018)

These data suggest that oxycodone-induced tolerance is mediated by PKC and that reversal of tolerance by ethanol or pregabalin may be a contributory factor in oxycodone overdose deaths.

Keyphrases

high glucose
protein kinase
diabetic rats
neuropathic pain
depressive symptoms
endothelial cells
electronic health record
postoperative pain
machine learning
sleep quality