Bone formation around unstable implants is enhanced by a WNT protein therapeutic in a preclinical in vivo model.

Benjamin R CoyacBrian LeahyZhijun LiGiuseppe SalviXing YinJohn B BrunskiJill A Helms

Published in: Clinical oral implants research (2020)

In a rat model, unstable implants undergo fibrous encapsulation. If the same unstable implants are treated with L-WNT3A at the time of placement, then it results in significantly more peri-implant bone and greater interfacial stiffness.

Keyphrases

molecular dynamics simulations
soft tissue
stem cells
cell proliferation
bone mineral density
protein protein
binding protein
cell therapy
amino acid
bone marrow
small molecule
newly diagnosed
postmenopausal women
ionic liquid
bone loss