Specific depletion of myeloid-derived suppressor cells by the chemotherapeutic agent 5-Fluorouracil enhances protective immune response in Paracoccidioidomycosis.

Nycolas Willian Preite Valéria de Lima Kaminski Bruno Montanari BorgesBianca Vieira Dos SantosVera Lúcia Garcia Calich Flavio Vieira Loures

Published in: The Journal of infectious diseases (2024)

5-FU treatment depletes lung-MDSCs of P. brasiliensis-infected mice resulting in enhanced immunity. The protective effect of 5-FU treatment in pulmonary PCM suggests that the specific depletion of MDSCs can be viewed as a potential immunotherapeutic tool for PCM.

Keyphrases

immune response
induced apoptosis
pulmonary hypertension
oxidative stress
adipose tissue
cell death
inflammatory response
insulin resistance
human health
pi k akt