Tanshinone I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC.

Jia ZhaoHongbin LiuZhixian HongWei LuoWenqing MuXiaorong HouGuang XuZhie FangLutong RenTingting LiuJincai WenWei ShiZiying WeiYongping YangWenjun ZouJun ZhaoXiaohe XiaoZhaofang BaiXiaoyan Zhan

Published in: Molecular medicine (Cambridge, Mass.) (2023)

Tan I specifically suppresses NLRP3 inflammasome activation by disrupting the association of NLRP3 and ASC, and exhibits protective effects in mouse models of LPS-induced septic shock and NASH. These findings suggest that Tan I is a specific NLRP3 inhibitor and may be a promising candidate for treating NLRP3 inflammasome-related diseases.

Keyphrases

nlrp inflammasome
lps induced
septic shock
inflammatory response
signaling pathway
mouse model