Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility.
Roman TikhomirovRobert H OakleyCali AndersonYirong XiangSami Al OthmanMatthew SmithSana YaarEleonora TorreJianying LiLeslie R WilsonDavid R GouldingIan J DonaldsonErika HarnoLuca SoattinHolly A ShielsGwilym M MorrisHenggui ZhangMark R BoyettJohn A CidlowskiPietro MesircaMatteo Elia MangoniAlicia D'SouzaPublished in: Circulation research (2024)
Our study registers a day-night rhythm in chromatin accessibility that accompanies diurnal cycles in ventricular myocytes. Our approaches directly implicate the cardiac GR in the myocyte excitability rhythm and mechanistically link the ZT12 surge in glucocorticoids to intrinsic VA propensity at this time.