BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma.
Mirela KremenovicAlfred A ChanBing FengLukas BäriswylSteve RobatelThomas GruberLi TangDelphine J LeeMirjam SchenkPublished in: Journal for immunotherapy of cancer (2022)
These findings provide mechanistic insights as well as rationale for the clinical translation of BCG hydrogel as cancer immunotherapy to overcome the current limitations of immunotherapies for the treatment of patients with melanoma.