Tucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane.
Natália A CamposMarcela de Sá Barreto da CunhaSandra F ArrudaPublished in: PloS one (2018)
Oxidative and inflammatory responses play an important role in the development and prevention of cancer, with both responses being modulated by phytochemical compounds. This study investigated the chemopreventive effect of tucum-do-cerrado fruit in rats treated with azoxymethane. Wistar rats were treated for 12 weeks with: a control diet (CT); a control diet + AOM (CT/DR); a control diet + 15% tucum-do-cerrado (TU); or a control diet + 15% tucum-do-cerrado + AOM (TU/DR). The association of tucum-do-cerrado and AOM (TU/DR) increased glutathione-S-transferase activity, decreased MDA levels, increased levels of COX2, TNFα and BAX, and decreased Bcl2/Bax ratio, compared to the CT/DR group. Carbonyl levels, IL-1β and IL-6 mRNA levels, and aberrant crypt foci showed no difference between the treatments. In conclusion, tucum-do-cerrado reduced lipid oxidative damage, induced a pro-inflammatory effect, and promoted a pro-apoptotic "environment" in rats treated with AOM; however no changes in aberrant crypts were observed.
Keyphrases
- oxidative stress
- physical activity
- weight loss
- computed tomography
- image quality
- editorial comment
- dual energy
- diabetic rats
- cell death
- induced apoptosis
- contrast enhanced
- magnetic resonance imaging
- rheumatoid arthritis
- endoplasmic reticulum stress
- squamous cell carcinoma
- papillary thyroid
- anti inflammatory
- young adults
- endothelial cells
- lymph node metastasis
- ischemia reperfusion injury
- heat stress
- childhood cancer
- pi k akt