Carcinoma en Cuirasse as the heralding sign of underlying HER-2 positive male breast cancer.
Mayank KapoorDeepak SundriyalAmit SehrawatMridul KhannaPublished in: BMJ case reports (2024)
Carcinoma en cuirasse (CeC) is an uncommon presentation of metastatic cutaneous carcinoma, most often originating from breast carcinoma. We present a case study of a man in his 30s exhibiting progressive skin thickening over the left chest, alongside appetite and weight loss. On examination, the patient had painless skin induration and palpable, matted, hard, immobile and non-tender axillary, cervical and inguinal lymphadenopathy. Imaging revealed metabolically active left cervical, retro pectoral, inguinal and bilateral axillary lymph nodes with muscle involvement, likely neoplastic. Histopathology demonstrated metastatic carcinoma, morphologically originating from the breast. CeC most often presents after therapy, but our case reveals that it may be a presenting sign of an occult malignancy. CeC should be differentiated from non-oncological causes of skin thickening. Detailed history, physical examination and appropriate radiological investigations are essential. Although rare in young individuals, neoplastic aetiology should be considered if the history and physical examination suggest it.
Keyphrases
- lymph node
- weight loss
- case report
- squamous cell carcinoma
- small cell lung cancer
- sentinel lymph node
- soft tissue
- mental health
- physical activity
- neoadjuvant chemotherapy
- wound healing
- radical prostatectomy
- bariatric surgery
- high resolution
- skeletal muscle
- prostate cancer
- ultrasound guided
- rectal cancer
- type diabetes
- mesenchymal stem cells
- single cell