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Structure-based discovery of CZL80, a caspase-1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility.

Yangshun TangBo FengYi WangHuiyong SunYi YouJie YuBin ChenCenglin XuYeping RuanSunliang CuiGang HuTingjun HouZhong Chen
Published in: British journal of pharmacology (2020)
Caspase-1 is essential for FS generation. CZL80 is a promising low MW inhibitor of FS and later enhanced epileptogenic susceptibility.
Keyphrases
  • cell death
  • induced apoptosis
  • small molecule
  • high throughput
  • endoplasmic reticulum stress
  • oxidative stress
  • single cell
  • chemotherapy induced