Empagliflozin in Heart Failure: Regional Nephron Sodium Handling Effects.
Veena S RaoJuan B Ivey-MirandaZachary L CoxJulieta Moreno-VillagómezChristopher MaulionLavanya BellumkondaJohn J ChangM Paul FieldDaniel R WiederinJaved ButlerSean P CollinsJeffrey M TurnerFrancis Perry WilsonSilvio E InzucchiChristopher S WilcoxDavid H EllisonJeffrey M TestaniPublished in: Journal of the American Society of Nephrology : JASN (2023)
Empagliflozin caused substantial redistribution of intra-renal sodium delivery and reabsorption, providing mechanistic substrate to explain some of the benefits of this class. Importantly, the large increase in sodium exit from the PT was balanced by distal compensation, consistent with SGLT2i excellent safety profile.