Combined inhibition of AURKA and HSF1 suppresses proliferation and promotes apoptosis in hepatocellular carcinoma by activating endoplasmic reticulum stress.

Zetian ShenLi YinHan ZhouXiaoqin JiChangchen JiangXixu ZhuXia He

Published in: Cellular oncology (Dordrecht) (2021)

Combined inhibition of AURKA and HSF1 shows an excellent anti-tumor effect on HCC cells in vitro and in vivo, which may be mediated by ERS. These findings suggest that both AURKA and HSF1 may serve as targets for HCC treatment.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
signaling pathway
heat shock
cell cycle arrest
oxidative stress
pi k akt
cell death
heat stress
heat shock protein
replacement therapy