Stratifying the Presymptomatic Phase of Genetic Frontotemporal Dementia by Serum NfL and pNfH: A Longitudinal Multicentre Study.
Carlo WilkeSelina ReichJohn C van SwietenBarbara BorroniRaquel Sanchez-ValleFermin MorenoRobert Jr LaforceCaroline GraffDaniela GalimbertiJames B RoweMario MasellisMaria C TartagliaElizabeth C FingerRik VandenbergheAlexandre de MendonçaFabrizio TagliaviniIsabel SantanaSimon DucharmeChris R ButlerAlexander GerhardJohannes LevinAdrian DanekMarkus OttoGiovanni FrisoniRoberta GhidoniSandro SorbiMartina BocchettaEmily ToddJens KuhleChristian Barronull nullJonathan D RohrerMatthis SynofzikPublished in: Annals of neurology (2021)
Blood NfL and pNfH provide dynamic stage-dependent stratification and, potentially, treatment response biomarkers in presymptomatic FTD, allowing demarcation of the conversion stage. The proposed biomarker cascade might pave the way towards a biomarker-based precision medicine approach to genetic FTD. ANN NEUROL 2021.