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Investigating eosin Y as a photocatalyst for the radical-dependent activity-based probing of deubiquitinating enzymes.

Neil C TaylorJoanna F McGouran
Published in: Organic & biomolecular chemistry (2021)
Eosin Y was assessed for its ability to induce a thiol-ene dependent protein-protein reaction in a metal-free, oxygen-tolerant, visible light mediated system. Protein-protein coupling efficiency under these mild conditions was comparable to previously reported UV-dependent conditions. The desired thiol-ene reaction was however limited within more complex biological systems.
Keyphrases
  • protein protein
  • visible light
  • small molecule
  • room temperature
  • electron transfer