Integrative single-cell and bulk transcriptomes analyses identify intrinsic HNSCC subtypes with distinct prognoses and therapeutic vulnerabilities.

Yibin Dai Ziyu Wang Yingcao Xia Jin Li Yaping Wu Yanling Wang Hongbing Jiang Jie Cheng

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

These findings reiterate molecular heterogeneity of HNSCC and advantages of scRNA-seq in pinpointing cellular diversities in complex cancer ecosystems. Our HNSCC iCMS regime might facilitate patient stratification and precision medicine.

Keyphrases

single cell
rna seq
high throughput
papillary thyroid
climate change
case report
gene expression
squamous cell carcinoma
young adults