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Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells.

Dongqing WangMengxue ZhouHui HuangLifo RuanHuiru LuJiayu ZhangJun ChenJimin GaoZhifang ChaiYi Hu
Published in: ACS applied bio materials (2019)
Validation of recent findings of hot mitochondria in cancer cells is critically needed, since a single fluorescent probe cannot rule out the possibility of varied cellular uptake efficiencies. Here we developed a ratiometric nanoprobe, named the mitochondria-targeted thermoresponsive-gold nanoparticle (MTT-AuNP), for analyzing mitochondrial temperatures. Results confirmed a relatively high mitochondrial temperature in murine bladder cancer MB49 cells. High temperatures in mitochondria might have far-reaching implications for developing mitochondria-targeted therapeutics.
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