Antibiotic treatment of bacterial vaginosis to prevent preterm delivery: Systematic review and individual participant data meta-analysis.

Mark A KlebanoffEwoud SchuitRonald F LamontPer-Göran LarssonHein J OdendaalAustin UgwumaduHerbert KissLjubomir PetricevicWilliam W AndrewsMatthew K HoffmanAndrew ShennanPaul T SeedRobert L GoldenbergLynda M EmelVinay BhandaruSteven WeinerMichael D Larsen

Published in: Paediatric and perinatal epidemiology (2023)

Clindamycin, but not metronidazole, was beneficial in studies providing IPD, but after imputing data from missing IPD studies, treatment of BV during pregnancy did not reduce PTD, nor prolong pregnancy, in any subgroup or when started earlier in gestation.

Keyphrases

systematic review
meta analyses
case control
big data
clinical trial
pregnant women
lipopolysaccharide induced
low birth weight
artificial intelligence
data analysis
double blind