Transformation of a low-grade follicular lymphoma into a composite lymphoma combining a high-grade B-cell lymphoma and a lymphoblastic neoplasm expressing Terminal deoxynucleotidyl Transferase: a case report.

Antonin BouroumeauEleonore KaphanClémentine LegrandTatiana RaskovalovaGautier SzymanskiClaire VettierChristine LefebvreMarie-Christine JacobAnne McLeerMichel PeuchmaurRémy GressinHervé Sartelet

Published in: Journal of medical case reports (2020)

These findings suggest a clonal relationship between the two types of lymphoma cells. Furthermore, they support the transformation of an acute follicular lymphoma into a composite lymphoma combining a high-grade B-cell lymphoma and a lymphoblastic neoplasm expressing terminal deoxynucleotidyl transferase. This case report highlights the possible transformation of follicular lymphoma into a highly aggressive and immature proliferation.

Keyphrases

low grade
high grade
diffuse large b cell lymphoma
case report
induced apoptosis
signaling pathway
liver failure
oxidative stress
respiratory failure
cell cycle arrest
aortic dissection
mechanical ventilation
pi k akt