ROS-Induced DNA Damage Associates with Abundance of Mitochondrial DNA in White Blood Cells of the Untreated Schizophrenic Patients.
I V ChestkovE M JestkovaE S ErshovaV G GolimbetT V LezheikoN Yu KolesinaO A DolgikhV L IzhevskayaG P KostyukS I KutsevN N VeikoSvetlana V KostyukPublished in: Oxidative medicine and cellular longevity (2018)
The leukocytes of the unmedicated SZ male patients with acute psychosis contain more mtDNA than the leukocytes of the male SZ patients treated with antipsychotic medications or the healthy controls. MtDNA content positively correlates with the level of 8-oxodG in the unmedicated SZ patients.
Keyphrases
- mitochondrial dna
- dna damage
- end stage renal disease
- copy number
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- oxidative stress
- induced apoptosis
- peripheral blood
- patient reported outcomes
- cell proliferation
- signaling pathway
- high glucose
- dna methylation
- diabetic rats
- antibiotic resistance genes
- stress induced
- wastewater treatment