Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice.

Shihab Kochumon R K Brojen Singh Sardar Sindhu Hossein Arefanian Texy JacobFatemah BahmanRasheeba Nizam Amal Hasan Reeby Thomas Fatema Al-RashedSteve ShenoudaAjit WilsonShaima AlbeloushiNourah AlmansourGhadeer AlhamarAshraf Al Madhoun Fawaz Alzaid Thangavel Alphonse Thanaraj Heikki A Koistinen Jaakko Tuomilehto Fahd Al-Mulla Rasheed Ahmad

Published in: Nutrients (2024)

These findings suggest that the sucrose-free C-HFD feeding in mice induces gut dysbiosis which associates with liver inflammation, steatosis, glucose intolerance and insulin resistance.

Keyphrases

high fat diet induced
insulin resistance
high fat diet
adipose tissue
metabolic syndrome
skeletal muscle
type diabetes
polycystic ovary syndrome
oxidative stress
blood pressure
blood glucose
glycemic control
weight loss