Rapamycin-Mediated mTOR Inhibition Reverses Drug Resistance to Adriamycin in Colon Cancer Cells.

Qiang MaZonghong ChangWei WangBiaomeng Wang

Published in: Hepato-gastroenterology (2016)

This study has indicated that the inhibition of the mTOR pathway reverses multidrug resistance in colorectal cancer cells, which is associated with increased autophagy, apoptosis and reduced mdr1 gene expression in drug-resistant cells treated with Adriamycin.

Keyphrases

drug resistant
multidrug resistant
cell cycle arrest
endoplasmic reticulum stress
gene expression
induced apoptosis
cell death
acinetobacter baumannii
oxidative stress
cell proliferation
dna methylation
signaling pathway
pi k akt
cystic fibrosis