Review article: Contemporary management of gastrointestinal, pancreatic and hepatic toxicities of immune checkpoint inhibitors.

Matthew J TownsendIsaac J BenqueMichael LiShilpa Grover

Published in: Alimentary pharmacology & therapeutics (2024)

Expanding clinical trial and cohort data have clarified the epidemiology and clinical characteristics of gastrointestinal, pancreatic and hepatic toxicities of ICIs. Guidelines, though valuable, remain based principally on retrospective cohort data. Quality prospective, controlled studies may refine algorithms for treatment and potential immunotherapy rechallenge.

Keyphrases

clinical trial
electronic health record
big data
machine learning
risk factors
study protocol
data analysis
risk assessment
phase ii
human health
combination therapy