ST2+ T-regulatory Cells in Renal Inflammation and Fibrosis following Ischemic Kidney Injury.

Vikram SabapathyAiri Price Nardos Tesfaye CheruRajkumar VenkatadriMurat Dogan Gabrielle CostlowSaleh MohammadRahul Sharma

Published in: Journal of the American Society of Nephrology : JASN (2024)

Our study identified the role of the IL-33/ST2 pathway in Tregs for resolution of kidney injury. The transcriptome of ST2+ Tregs was enriched for reparative factors including AREG. Lack of ST2 or AREG in Tregs worsened kidney injury. Tregs protected kidney organoids from hypoxia in ST2 and AREG-dependent manner. Thus Treg-based approaches could be of benefit for resolution of renal injury.

Keyphrases

induced apoptosis
oxidative stress
single molecule
rna seq
brain injury
cell proliferation
blood brain barrier
endoplasmic reticulum stress
pi k akt