Nose to brain delivery of naringin-loaded chitosan nanoparticles for potential use in oxaliplatin-induced chemobrain in rats: Impact on oxidative stress, cGAS/STING and HMGB1/RAGE/TLR2/MYD88 inflammatory axes.

Diana M F HannaJohn YoushiaSarah Farid FahmyMina Y George

Published in: Expert opinion on drug delivery (2023)

Intranasalnaringin-loaded chitosan nanoparticles showed superior amelioration ofoxaliplatin-induced chemobrain in rats at a dose 267-fold lower to thatadministered orally. The potential involvement of cGAS/STINGand HMGB1/RAGE/TLR2/MYD88 pathways in the mechanistic process of eitheroxaliplatin-induced chemobrain or naringin-mediated neuroprotection was evidenced.

Keyphrases

diabetic rats
oxidative stress
drug delivery
toll like receptor
high glucose
wound healing
inflammatory response
immune response
cancer therapy
endothelial cells
nuclear factor
white matter
induced apoptosis
signaling pathway
climate change
heat shock