A tri-metallic palladium complex with breast cancer stem cell potency.

Arvin EskandariArunangshu KunduAlice JohnsonSanjib KarmakarSushobhan Ghosh Kogularamanan Suntharalingam

Published in: Dalton transactions (Cambridge, England : 2003) (2020)

A multi-nuclear, triangular-shaped palladium(ii) complex is shown to equipotently kill bulk cancer cells and cancer stem cells (CSCs) in the micromolar range. The palladium(ii) complex evokes CSC apoptosis by entering CSC nuclei and damaging genomic DNA.

Keyphrases

cancer stem cells
stem cells
reduced graphene oxide
oxidative stress
endoplasmic reticulum stress
cell death
gene expression
cell free
gold nanoparticles
dna methylation
young adults
cell therapy
genome wide