Increasing Brain Gamma Activity Improves Episodic Memory and Restores Cholinergic Dysfunction in Alzheimer's Disease.

Alberto BenussiValentina CantoniMario GrassiLucie BrechetChristoph M MichelAbhishek DattaChris ThomasStefano GazzinaMaria Sofia CotelliMarta BianchiEnrico PremiYasmine GadolaMaria CotelliMarta PengoFederica PerroneMaria ScolaroSilvana ArchettiEino SoljeAlessandro PadovaniÁlvaro Pascual-Leone Barbara Borroni

Published in: Annals of neurology (2022)

Precuneus γ-tACS, able to increase γ-power activity on the posterior brain regions, showed a significant improvement of episodic memory performances, along with restoration of intracortical excitability measures of cholinergic transmission. Response to γ-tACS was dependent on genetic factors and disease stage. ANN NEUROL 2022;92:322-334.

Keyphrases

resting state
white matter
working memory
functional connectivity
cerebral ischemia
cognitive decline
multiple sclerosis
gene expression
copy number