Malachite green: a long-buried water-soluble AIEgen with near-infrared fluorescence for living cell nucleus staining.

Yuan LuoLihua ZhouLili DuYangzi XieXiang-Yang LouLintao CaiBen Zhong TangPing GongPengfei Zhang

Published in: Chemical communications (Cambridge, England) (2024)

Fluorescent imaging probes are crucial for exploring nucleus-related cellular events in live cells. Ideal probes should be photostable, small-sized, highly contrasted, and low in background. Here, we discovered that malachite green is a water-soluble near-infrared luminogen with aggregation-induced emission properties. Importantly, it can be used for living cell nucleus staining in a wash-free manner.

Keyphrases

water soluble
living cells
single cell
single molecule
small molecule
cell therapy
fluorescence imaging
high resolution
cell cycle arrest
stem cells
oxidative stress
fluorescent probe