Human umbilical cord mesenchymal stem cells ameliorate erectile dysfunction in rats with diabetes mellitus through the attenuation of ferroptosis.

Huan FengQi LiuZhiyao DengHao LiHuajie ZhangJingyu SongXiaming LiuJihong LiuBo WenTao Wang

Published in: Stem cell research & therapy (2022)

HUCMSCs can effectively and safely alleviate erectile dysfunction in T1DM and T2DM ED rats, while restoring erectile function by attenuating diabetes-induced ferroptosis in CCSMCs. Additionally, this study provides significant evidence for the development of HUCMSCs as a viable therapeutic strategy for DMED.

Keyphrases

umbilical cord
mesenchymal stem cells
glycemic control
cell death
endothelial cells
type diabetes
high glucose
emergency department
bone marrow
cardiovascular disease
cell therapy
diabetic rats
induced pluripotent stem cells
skeletal muscle
oxidative stress
metabolic syndrome
weight loss
insulin resistance