Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function.
Sylvain LehmannSusanna Schraen-MaschkeJean-Sébastien VidalConstance DelabyFrédéric BlancClaire PaquetBernadette AllinquantStéphanie BomboisAudrey GabelleOlivier HanonPublished in: Journal of neurology, neurosurgery, and psychiatry (2023)
Plasma P-tau181 effectively detects Aβ+ status and conversion to dementia, confirming the value of this blood biomarker for the management of AD. However, renal function significantly modifies its levels and may thus induce diagnostic errors if not taken into account.