The Ubiquitin Ligase RBX2/SAG Regulates Mitochondrial Ubiquitination and Mitophagy.
Wenjuan WangErmin LiJianqiu ZouChen QuJuan AyalaYuan WenMd Sadikul IslamNeal L WeintraubDavid J R FultonQiangrong LiangJiliang ZhouJin-Bao LiuJie LiYi SunHuabo SuPublished in: Circulation research (2024)
These findings identify RBX2-CRL5 as a mitochondrial Ub ligase that regulates mitophagy and cardiac homeostasis in a Parkin-independent, PINK1-dependent manner.