Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice.

Kiyoshi Saeki Wanglong Qiu Richard A Friedman Samuel S Pan Jordan Lu Shu Ichimiya Iok In Christine Chio Carrie J Shawber Jan K Kitajewski Jianhua Hu Gloria H Su

Published in: Cancer research communications (2022)

significantly improved the survival of an aggressive mouse model for PDAC and provided preclinical evidence that Notch4 and Pcsk5 are novel targets for PDAC therapies.

Keyphrases

mouse model
cell proliferation
high fat diet induced
type diabetes
stem cells
metabolic syndrome
wild type
adipose tissue
insulin resistance
low density lipoprotein