Molecularly imprinted and cladded polymers for constructing a portable plasmonic immunoassay for peptides in biofluids.
Zhanchen GuoQi ZhangRongrong XingZhen LiuPublished in: Chemical communications (Cambridge, England) (2023)
Using two molecularly imprinted and cladded polymers (cMIPs), an inexpensive, fast and portable plasmonic immuno-sandwich assay (PISA) was rationally developed for high-specificity and ultra-sensitive detection of C-peptide in urine. The dual cMIPs-based PISA allowed healthy individuals to be distinguished from diabetes patients and exhibited several significant merits over existing immunoassays, holding great promise in clinical diagnosis.
Keyphrases
- molecularly imprinted
- sensitive detection
- solid phase extraction
- end stage renal disease
- quantum dots
- type diabetes
- ejection fraction
- newly diagnosed
- cardiovascular disease
- chronic kidney disease
- label free
- high throughput
- high resolution
- machine learning
- big data
- glycemic control
- low cost
- energy transfer
- patient reported outcomes
- loop mediated isothermal amplification
- deep learning
- insulin resistance
- tandem mass spectrometry