New World feline APOBEC3 potently controls inter-genus lentiviral transmission.

Yoriyuki KonnoShumpei NagaokaIzumi KimuraKeisuke YamamotoYumiko KagawaRyuichi KumataHirofumi AsoMahoko Takahashi UedaSo NakagawaTomoko KobayashiYoshio KoyanagiKei Sato

Published in: Retrovirology (2018)

To the best of our knowledge, this is the first study suggesting that the host A3 protein potently controls inter-genus lentiviral transmission. Our findings provide the first evidence suggesting that the co-evolutionary arms race between lentiviruses and mammals has occurred in the New World.

Keyphrases

gene therapy
healthcare
gene expression
amino acid
binding protein
dna methylation
small molecule