Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty.

Jodie L MorrisHayley L LetsonPeter McEwenErik BirosConstantin DlaskaKaushik HazratwalaMatthew WilkinsonGeoffrey P Dobson

Published in: Journal of orthopaedic surgery and research (2021)

Data suggest that IA administration of ALM is superior to TXA for reducing postoperative systemic and joint inflammation and promoting restoration of healthy joint tissue architecture in a rat model of TKA. Further studies are warranted to assess the clinical translational potential of ALM IA solution to improve patient outcomes following arthroplasty.

Keyphrases

oxidative stress
patients undergoing
risk assessment
artificial intelligence
drug induced