High-Resolution 7T MR Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis.
Mirco CosottiniGraziella DonatelliMauro CostagliElena Caldarazzo IencoDaniela FrosiniI PesaresiLaura BiagiG SicilianoMichela TosettiPublished in: AJNR. American journal of neuroradiology (2015)
The combined high spatial resolution and sensitivity to paramagnetic substances of 7T MR imaging demonstrate in vivo signal changes of the cerebral motor cortex that resemble the distribution of activated microglia within the cortex of patients with amyotrophic lateral sclerosis. Cortical thinning and signal hypointensity of the deep layers of the primary motor cortex could constitute a marker of upper motor neuron impairment in patients with amyotrophic lateral sclerosis.
Keyphrases
- amyotrophic lateral sclerosis
- high resolution
- contrast enhanced
- subarachnoid hemorrhage
- inflammatory response
- functional connectivity
- magnetic resonance imaging
- drinking water
- neuropathic pain
- mass spectrometry
- spinal cord injury
- solar cells
- brain injury
- cerebral blood flow
- spinal cord
- high speed
- liquid chromatography