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Miniaturization: How many cells are needed to build a tooth?

Daria LarionovaHervé LesotAnn Huysseune
Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)
Our observations indicate that in this system, one single odontoblast fulfills roles normally exerted by a large and communicating cell population. First-generation teeth in medaka thus provide an exciting model to study integration of multiple functions into a single cell.
Keyphrases
  • single cell
  • induced apoptosis
  • rna seq
  • cell cycle arrest
  • high throughput
  • cell therapy
  • stem cells
  • cell death
  • endoplasmic reticulum stress
  • bone marrow
  • oxidative stress
  • cone beam computed tomography