Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer.

Efrat DotanDana Backlund CardinHeinz-Josef LenzWells MessersmithBert O'NeilSteven J CohenCrystal S DenlingerSafi ShahdaIgor AstsaturovAnn M KapounRainer K BrachmannShailaja UttamsinghRobert J StaggColin Weekes

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Ipafricept can be administered with nab-paclitaxel + gemcitabine with reasonable tolerance. Wnt pathway remains a therapeutic target of interest in mPDAC.

Keyphrases

stem cells
cell proliferation
advanced non small cell lung cancer
locally advanced
squamous cell carcinoma
epidermal growth factor receptor
chemotherapy induced